Find information about common, infrequent and rare side effects of Hydrocodone-Acetaminophen Oral. Find information about common, infrequent and rare side effects of Hydrocodone-Ibuprofen Oral. Summary. Numbness and tingling is found among people who take Norco, especially for people who are female, 50-59 old , have been taking the drug for 6 - 12 months, also take medication Xanax, and have Neck pain. In Summary. Commonly reported side effects of hydrocodone/ibuprofen include: drowsiness and dyspepsia. See below for a comprehensive list of adverse effects. Norco (hydrocodone bitartrate and acetaminophen) is an opioid analgesic and antitussive (cough suppressant) combined with a pain reliever (analgesic) used to treat moderate to fairly severe pain. Applies to hydrocodone: compounding powder, oral capsule extended release, oral tablet extended release General The most commonly reported side effects included constipation , nausea, vomiting, fatigue, upper respiratory tract infection , dizziness, headache, and somnolence. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydrocodone is an opioid commonly used as a pain killer and as a cough suppressant. Considered habit-forming, hydrocodone is one of two main ingredients in the prescription painkiller Vicodin. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Norco 5/325 (hydrocodone acetaminophen and bitartrate) is an opioid analgesic and antitussive (cough suppressant) combined with a fever reducer and pain reliever and used to treat moderate to fairly severe pain.